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α‑Conotoxin TxID from Conus textile


Doron scientific is pleased to offer a Novel α‑Conotoxin TxID from Conus textile That Potently Blocks Rat α3β4 Nicotinic Acetylcholine Receptors.

Novel α‑Conotoxin TxID from Conus textile

The α3β4 nAChR may be key targets of drugs to treat difficult miscellaneous diseases, such as addiction, chronic pain, obesity, cervical cancer and lung carcinoma etc.

The α-conotoxin TxID has been fully folded and tested its activity on α3β4 nicotinic acetylcholine receptors (nAChR) in our lab, which has activity on α3β4 nAChR.

Selective α3β4 nAChR antagonists (TxID etc) can reduce nicotine self-administration in rats, demonstrating the role of the α3β4 nAChR in nicotine dependence and drug-seeking behavior.

Hypothalamic α3β4 nAChR subtype was critical for food intake and body weight in mice, which could be important to modulate appetite and control obesity (Mineur et al., Science 2011, 332, 1330-1332).

Special Conditions This product is a toxin.

Contact us via email at: info@doronscientific.com

Product Size and Price

Size 100 x 1mg vial, For a quote Please contact us via email: info@doronscientific.com

Size 250 x 1mg vial, For a quote Please contact us via email: info@doronscientific.com

Size 500 x 1mg vial, For a quote Please contact us via email: info@doronscientific.com






References: Dongting Zhangsun, Sulan Luo et al. J Med Chem.2013, 56, 9655−9663. attached please find PDF file

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